ATHN 8: US Cohort Study of Previously Untreated Patients with Congenital Hemophilia
ATHN 8 – PUPs Matter is the first national cohort study focused on previously untreated patients (PUPs) that will provide a platform for ongoing clinical research studies to improve the outcomes of this vulnerable population. In-depth clinical and laboratory data will be collected, especially during high-risk periods for antibody development.
ATHN 8 is a longitudinal, observational study aimed at determining the percentage of PUPs with confirmed inhibitors within the first 50 exposure days. In addition, the study seeks to determine:
- Risk factors associated with inhibitor development in the previously untreated population
- Percentage of eligible patients enrolled at each treatment site
- Mean age at diagnosis and first exposure to factor replacement treatment
- Number of exposure days prior to inhibitor development and the number of transient inhibitors.
With a key focus on data quality, ATHN 8 data collected will include demographics, medical and hemophilia history, birth and family history, bleeding events, clotting factor replacement and non-factor replacement products used for treatment, inhibitor testing results, and HTC or hospital visits during study participation.
ATHN 8 is being conducted in collaboration with the Blood Center of Wisconsin.
To learn more about ATHN 8, email ATHN at firstname.lastname@example.org.